Unique - where else can you walk amongst the wildlife in a National Park/UNESCO World Heritage site
I have been fortunate to visit Mana Pools on an almost annual basis over the last 12 years (I am now the Mana Pools 'Destination Expert' on Tripadvisor).
It is a magical place - a series of pools, where the Zambezi river once flowed. These pools retain water all year around, so along with the Zambezi, provide a vital resource for animals from far and wide during the long, hot dry season (August - October). We always visit in October - the end of the dry season and nicknamed the 'suicide' month for good reason. It is blisteringly hot, and Mana is not a comfortable place to be at this time of year. But the reward for this discomfort is in the game viewing. Animal numbers are at their peak and they are easy to see due to the lack of vegetation.
On my trips, I have always seen elephant (Mana is the only place I know of where they have learnt to stand on their rear legs to reach up a little higher to graze the Accacia Albida trees which are so characteristic of Mana), hippo, crocodile, kudu, eland, monitor lizard, mongeese of various types, baboons, zebra, vervet monkeys, cape buffalo, impala, hyena, lion & jackal. Most of these have at one time or another walked right through our camp! We have also been fortunate to see on most visits the rare African Painted Dog - Mana is one of the few places in Africa where you stand a good chance of seeing these wonderful animals. We have also had a number of wonderful 'one-off' sightings over the years - leopard, python nyala, bush buck and last year, three cheetah on an impala kill. A very rare sighting as Mana lacks wide open spaces and so is not really cheetah country at all. All of the animals I mention have been seen without the aid of professional guides - we are just a group of friends who enjoy visiting the African bush. Most of the time we walk rather than drive - after viewing wildlife on foot, the experience from the back of a vehicle just isn't the same.
In addition to the animals mentioned, Mana is a 'birding' paradise - so many species to see I couldn't begin to list them, but a personal favourite of mine are the noisy carmine bee beaters who nest in burrows in the sandy river banks.
In the unlikely event you grow tired of looking at animals, the scenery is fantastic - the almost parkland-like abandoned river terraces, the majestic Zambezi and the hazy mountains of Zambia. Always try to be on the river bank just before sunset, a beer or G&T in hand and just watch & listen!
Mana is not the easiest place in the world to get too, but there are a number of safari operators who will take the logistical strain on your behalf, and if you don't want to 'go it alone' and use National Parks camping (or lodge) facilities, there are a number of very good camps (one or two permanent, like Ruckomechi, others seasonal, like Goliath Safaris who have their camp inside the National Park and are run by the wonderful Stretch & Flo)